Section one: Contracting authority
one.1) Name and addresses
University of Dundee
Procurement, 3rd Floor, Tower Building, Nethergate
Dundee
DD1 4HN
Contact
Mary Kirkpatrick
Telephone
+44 1382386604
Country
United Kingdom
NUTS code
UKM71 - Angus and Dundee City
Internet address(es)
Main address
Buyer's address
https://www.publiccontractsscotland.gov.uk/search/Search_AuthProfile.aspx?ID=AA00105
one.2) Information about joint procurement
The contract is awarded by a central purchasing body
one.3) Communication
The procurement documents are available for unrestricted and full direct access, free of charge, at
www.publiccontractsscotland.gov.uk
Additional information can be obtained from the above-mentioned address
Tenders or requests to participate must be submitted electronically via
www.publicontractsscotland.gov.uk
Electronic communication requires the use of tools and devices that are not generally available. Unrestricted and full direct access to these tools and devices is possible, free of charge, at
www.publicontractsscotland.gov.uk
one.4) Type of the contracting authority
Body governed by public law
one.5) Main activity
Education
Section two: Object
two.1) Scope of the procurement
two.1.1) Title
Term Framework for the Provision of Chemistry Synthesis and other Chemistry Services Outsourcing Framework
Reference number
UoD-LAB031-TC-2023
two.1.2) Main CPV code
- 73110000 - Research services
two.1.3) Type of contract
Services
two.1.4) Short description
Second-Generation Framework for the provision of Chemistry Synthesis and other Chemistry Services Outsourcing with initial term of two (2) years with the option to extend for up to 2 x 12 months, if required, at the sole discretion of the University and subject to ongoing satisfactory performance by the appointed Service Providers.
The Services will include:
1. FTE rate for provision of chemistry support for medicinal chemistry programme(s), typically making 50mg samples of compounds for initial biological evaluation. For actives, re-synthesis on a larger scale may be required (typically 0.5g to 5g scale). The ability to carry out array chemistry is important;
2.Bespoke piece(s) of chemistry e.g. synthesis of a defined list of compounds, typically at <50mg scale;
3. Scale up of chemistry, up to 200g;
4.Chiral separation by crystallization or SFC/Chiral HPLC on (up to) gram scale.
5.Synthesis of intermediates at 5-100g;
For all of these, a purity level will be defined. This will depend on the phase of the project, but typically is >95% purity and for scale up> 98% purity with no impurity >0.5%;
6. Experimental write-ups, when requested, including compound characterization by 1H NMR, 13C NMR and LCMS or UPLC/MS for publications, in-vivo release, tech-transfer to DDU or other CRO for patent purposes.
two.1.5) Estimated total value
Value excluding VAT: £4,000,000
two.1.6) Information about lots
This contract is divided into lots: No
two.2) Description
two.2.2) Additional CPV code(s)
- 73110000 - Research services
two.2.3) Place of performance
NUTS codes
- UKM71 - Angus and Dundee City
Main site or place of performance
Biological Chemistry & Drug Discovery (BCDD), University of Dundee
two.2.4) Description of the procurement
This Second-Generation Framework is required to provide a quick route to market for the provision of Chemistry Synthesis and other Chemistry Services. The initial contract term will be two (2) years, with the option to extend for 2 x 12 months, if required, at the sole discretion of BCDD and subject to ongoing satisfactory performance by the appointed Service Providers
The Chemistry Synthesis and Other Chemistry Services required will include:
1. FTE rate for provision of chemistry support for medicinal chemistry programme(s), typically making 50mg samples of compounds for initial biological evaluation. For actives, re-synthesis on a larger scale may be required (typically 0.5g to 5g scale). The ability to carry out array chemistry is important;
2. Bespoke piece(s) of chemistry e.g. synthesis of a defined list of compounds, typically at <50mg scale;
-Scale up of chemistry, up to 200g;
-Chiral separation by crystallization or SFC/Chiral HPLC on (up to) gram scale.
-Synthesis of intermediates at 5-100g;
For all of these, a purity level will be defined. This will depend on the phase of the project, but typically is >95% purity and for scale up> 98% purity with no impurity >0.5%;
-Experimental write-ups, when requested, including compound characterization by 1H NMR, 13C NMR and LCMS or UPLC/MS for publications, in-vivo release, tech-transfer to DDU or other CRO for patent purposes.
The subsequent route to market will be via Mini Comp under the Framework.
two.2.5) Award criteria
Quality criterion - Name: 1. Account /Project Management & Communication / Weighting: 4
Quality criterion - Name: 2.Range of Chemistry Synthesis and other Chemistry Services available. / Weighting: 10
Quality criterion - Name: 3. Service Levels / Weighting: 10
Quality criterion - Name: 4. Audit Control & Record Keeping / Weighting: 10
Quality criterion - Name: 5. Sample CVs / Weighting: 2
Quality criterion - Name: 6. Added Value / Weighting: 4
Price - Weighting: 60
two.2.6) Estimated value
Value excluding VAT: £4,000,000
two.2.7) Duration of the contract, framework agreement or dynamic purchasing system
Duration in months
24
This contract is subject to renewal
Yes
Description of renewals
Option to extend Framework for maximum 2 x further years, subject to ongoing need and satisfactory performance by the appointed service providers.
two.2.10) Information about variants
Variants will be accepted: No
two.2.11) Information about options
Options: No
two.2.13) Information about European Union Funds
The procurement is related to a project and/or programme financed by European Union funds: No
Section three. Legal, economic, financial and technical information
three.1) Conditions for participation
three.1.1) Suitability to pursue the professional activity, including requirements relating to enrolment on professional or trade registers
List and brief description of conditions
Please provide a minimum of 3 examples of similar projects/contracts previously undertaken in the last 3 years.
Please provide details of the technicians or technical bodies that you can call upon , particularly in respect of quality control of the Chemistry synthesis services to be provided:
Bidders are required to confirm that they and/or their proposed personnel have as a minimum the following relevant educational and professional qualifications:
Team Leaders with responsibility for the day-to-day management of UoD’s projects must be educated to PhD level or equivalent;
Chemists carrying out the project work require to be educated to BSC level or above;
three.1.2) Economic and financial standing
Selection criteria as stated in the procurement documents
three.1.3) Technical and professional ability
Selection criteria as stated in the procurement documents
three.2) Conditions related to the contract
three.2.3) Information about staff responsible for the performance of the contract
Obligation to indicate the names and professional qualifications of the staff assigned to performing the contract
Section four. Procedure
four.1) Description
four.1.1) Type of procedure
Open procedure
four.1.3) Information about a framework agreement or a dynamic purchasing system
The procurement involves the establishment of a framework agreement
Framework agreement with several operators
Envisaged maximum number of participants to the framework agreement: 6
four.1.8) Information about the Government Procurement Agreement (GPA)
The procurement is covered by the Government Procurement Agreement: Yes
four.2) Administrative information
four.2.2) Time limit for receipt of tenders or requests to participate
Originally published as:
Date
26 April 2024
Local time
5:00pm
Changed to:
Date
22 May 2024
Local time
12:00pm
See the change notice.
four.2.4) Languages in which tenders or requests to participate may be submitted
English
four.2.6) Minimum time frame during which the tenderer must maintain the tender
Tender must be valid until: 31 May 2024
four.2.7) Conditions for opening of tenders
Date
1 May 2024
Local time
12:00pm
Place
Procurement, Level 3, Tower Building, University of Dundee, Nethergate, Dundee DD1 4HN
Information about authorised persons and opening procedure
Mary Kirkpatrick, Category Manager duly authorised.
Section six. Complementary information
six.1) Information about recurrence
This is a recurrent procurement: No
six.2) Information about electronic workflows
Electronic ordering will be used
Electronic invoicing will be accepted
Electronic payment will be used
six.3) Additional information
NOTE: To register your interest in this notice and obtain any additional information please visit the Public Contracts Scotland Web Site at https://www.publiccontractsscotland.gov.uk/Search/Search_Switch.aspx?ID=761553.
The buyer has indicated that it will accept electronic responses to this notice via the Postbox facility. A user guide is available at https://www.publiccontractsscotland.gov.uk/sitehelp/help_guides.aspx.
Suppliers are advised to allow adequate time for uploading documents and to dispatch the electronic response well in advance of the closing time to avoid any last minute problems.
(SC Ref:761553)
Download the ESPD document here: https://www.publiccontractsscotland.gov.uk/ESPD/ESPD_Download.aspx?id=761553
six.4) Procedures for review
six.4.1) Review body
Dundee Sheriff Court
West Bell Street
Dundee
DD1 1HN
Country
United Kingdom
six.4.2) Body responsible for mediation procedures
Dundee Sheriff Court
West Bell Street
Dundee
DD1 4HN
Country
United Kingdom