Scope
Reference
C367576
Description
Tenders were invited to carry out a range of project delivery options, to deliver against stages 1, 2 and 3 as described below:
Stage 1: This case study is to support the UK FSA's policy need to determine which TAs are the most potent (neuro)toxicants so as to prioritise specific substances and inform decisions on the UK's monitoring of these alkaloids in foods. An integral part of this aim is to confirm that neurotoxicity is the primary mode of action of these alkaloids. This aim will be achieved using a tiered-testing strategy of in silico, in vitro and 'omics NAMs. This will then be extended to other plant alkaloids such as glycoalkaloids and pyridazine alkaloids.
Stage 2: To derive a HBGV for human exposure for the top priority, i.e. most potent substance within the class of TAs. This will utilise physiologically-based kinetic (PBK) modelling and quantitative in vitro to in vivo extrapolation (QIVIVE). This will then be extended to other plant alkaloids such as glycoalkaloids and pyridazine alkaloids.
Stage 3: From a methodological perspective, a broader third objective of the case study is to evaluate and attempt to build confidence within the FSA in the application of a series of relevant NAMs that have been integrated in a manner to address policy needs. These NAMs are tiered and incorporate existing human in vivo data as well as new testing on human in vitro cell lines, to maximise the relevance and accuracy to human food safety.
Contract 1. Utilising in silico, in vitro and ‘omics New Approach Methodologies (NAMs) for p
Supplier
Contract value
- £488,375.50 excluding VAT
- £586,050.60 including VAT
Above the relevant threshold
Award decision date
25 August 2025
Standstill period
- End: 18 September 2025
- 8 working days
Earliest date the contract will be signed
22 September 2025
Contract dates (estimated)
- 29 September 2025 to 10 May 2028
- 2 years, 7 months, 12 days
Main procurement category
Services
CPV classifications
- 73000000 - Research and development services and related consultancy services
Procedure
Procedure type
Direct award
Supplier
University of Birmingham
- Public Procurement Organisation Number: PHCQ-3464-LVTM
Edgbaston
Birmingham
B15 2TT
United Kingdom
Email: welcome@contacts.bham.ac.uk
Website: http://www.birmingham.ac.uk
Region: UKG31 - Birmingham
Small or medium-sized enterprise (SME): No
Voluntary, community or social enterprise (VCSE): No
Supported employment provider: No
Public service mutual: No
Associated people/organisations:
N/A
Contract 1. Utilising in silico, in vitro and 'omics New Approach Methodologies (NAMs) for p
Contracting authority
Food Standards Agency
- Public Procurement Organisation Number: PJRM-6866-LYYX
YO1 7PR
York
YO1 7PR
United Kingdom
Region: UKE21 - York
Organisation type: Public authority - central government