Scope
Reference
C28850
Description
This project will comprehensively test different vaccine approaches against HEV in pigs, applying a range of methods from measuring Abs to the protective signature in the liver. The hypothesis is that the vaccines may not be able to prevent infection, but to reduce HEV replication to an extend that onward transmission between pigs would no longer be possible. To that extend the approaches to investigate the above concept are as follows: · Use of an oral vaccine, a parantal vaccine, and the combination of the above - as prime/boost approach · In all cases the project will analyse the levels and quality of Abs generated. · The project will further analyse the induction of T cells by the vaccine - such analysis will be undertaken via liver and gut samples (locally) as well as systemically (in blood). The project can use flow cytometry, RNASeq or scRNASeq to demonstrate the full spectrum of functional T cells induced. The most promising candidate approach will then also be used for a challenge study.
Contract 1. Vaccine approaches against HEV in pigs
Supplier
Contract value
- £68,894 excluding VAT
- £82,672.80 including VAT
Below the relevant threshold
Date signed
4 July 2025
Contract dates
- 7 July 2025 to 30 September 2027
- Possible extension to 30 September 2028
- 3 years, 2 months, 25 days
Description of possible extension:
This Agreement shall begin on the Commencement Date and shall continue in force until the Expiry Date unless terminated or extended by mutual written agreement of the Parties, or otherwise terminated in accordance with this Clause 11.
Main procurement category
Services
CPV classifications
- 73000000 - Research and development services and related consultancy services
Contract locations
- UK - United Kingdom
Procedure
Procedure type
Below threshold - without competition
Supplier
University of Surrey
Stag Hill, University Campus
Guildford
GU2 7XH
United Kingdom
Region: UKJ25 - West Surrey
Small or medium-sized enterprise (SME): No
Voluntary, community or social enterprise (VCSE): No
Contract 1. Vaccine approaches against HEV in pigs
Contracting authority
ANIMAL AND PLANT HEALTH AGENCY
- Public Procurement Organisation Number: PBHC-6261-BLLQ
Seacole Building, 2 Marsham Street
London
SW1P 4DF
United Kingdom
Contact name: THE ANIMAL AND PLANT HEALTH AGENCY ("APHA")
Email: procurement@defra.gov.uk
Region: UKI32 - Westminster
Organisation type: Public authority - central government