- Scope of the procurement
- Lot 1. Enzymes
- Lot 2. Nucleotides
- Lot 3. Primers and DNA Oligos
- Lot 4. Gel Consumables
- Lot 5. Buffers
- Lot 6. Competent Cells
- Lot 7. RNA/DNA Synthesis and Purification Kits
- Lot 8. Media
- Lot 9. CleanCap
- Lot 10. Columns
- Lot 11. AAV material
- Lot 12. ELISA kits
- Lot 13. Reporter assay
- Lot 14. Transfection reagents
Section one: Contracting authority
one.1) Name and addresses
CENTRE FOR PROCESS INNOVATION LIMITED
Wilton
REDCAR
TS104RF
Contact
CPI Procurement
Telephone
+44 1740625716
Country
United Kingdom
NUTS code
UKC12 - South Teesside
Internet address(es)
Main address
https://ne1procurementservices.com/content/live_tenders.php
one.2) Information about joint procurement
The contract is awarded by a central purchasing body
one.3) Communication
The procurement documents are available for unrestricted and full direct access, free of charge, at
https://ne1procurementservices.com/content/live_tenders.php
Additional information can be obtained from the above-mentioned address
Tenders or requests to participate must be submitted electronically via
https://ne1procurementservices.com/content/live_tenders.php
one.4) Type of the contracting authority
Body governed by public law
one.5) Main activity
Other activity
Research and development
Section two: Object
two.1) Scope of the procurement
two.1.1) Title
2274 - Consumables for Molecular Biology
Reference number
2274
two.1.2) Main CPV code
- 24000000 - Chemical products
two.1.3) Type of contract
Supplies
two.1.4) Short description
The aim of this framework is to establish preferred and CPI approved suppliers under a variety of supply categories to provide a range of materials for use by CPI, mainly to support the development of CPI's molecular biology capability for production of therapeutic proteins and nucleic acids. Please see our response to tender document (2274 - RTTBO) for the information that bidders are required to provide in order to be considered as a CPI approved supplier. Bids will be accepted from potential suppliers for one, multiple and all lots, and bidders are not required to supply the entirety of an individual lots product list to be considered as an approved supplier.
two.1.5) Estimated total value
Value excluding VAT: £3,900,000
two.1.6) Information about lots
This contract is divided into lots: Yes
Tenders may be submitted for all lots
two.2) Description
two.2.1) Title
Enzymes
Lot No
1
two.2.2) Additional CPV code(s)
- 24000000 - Chemical products
two.2.3) Place of performance
NUTS codes
- UK - United Kingdom
two.2.4) Description of the procurement
We would expect any successful suppliers to also be able to supply other enzymes (restriction, ligation, reverse transcription, alternative polymerase). Being able to supply GMP grade enzymes is also advantageous.
Enzymes purchased on this tender will be used in molecular biology applications to develop R&D processes at CPI at both small scale and large scale, therefore custom bulk volumes of these enzymes are likely to be required.
Enzymes should be tested for exonuclease and endonuclease activity. All enzymes should be provided with the manufacturer's definition of a "unit" of enzyme e.g. "one U of enzyme is defined as the amount of enzyme required to digest xµg of DNA at 37°C in xx minutes in a total reaction volume of xxµl".
two.2.5) Award criteria
Price is not the only award criterion and all criteria are stated only in the procurement documents
two.2.7) Duration of the contract, framework agreement or dynamic purchasing system
Duration in months
48
This contract is subject to renewal
No
two.2.10) Information about variants
Variants will be accepted: No
two.2.11) Information about options
Options: No
two.2) Description
two.2.1) Title
Nucleotides
Lot No
2
two.2.2) Additional CPV code(s)
- 24000000 - Chemical products
two.2.3) Place of performance
NUTS codes
- UK - United Kingdom
two.2.4) Description of the procurement
dNTPs and NTPs will be required for use in multiple PCR applications; in vitro transcription; mRNA/saRNA synthesis and cloning. dNTPs and NTPs should be possible of being supplied in sodium or tris salt form and confirmed as RNase, DNase and protease free. The ability to supply alternative salt forms, such as lithium, would be advantageous.
These dNTPs and NTPs will be used for a range of applications in both small scale and large scale, it would be beneficial if they could be supplied in custom bulk volumes.
two.2.5) Award criteria
Price is not the only award criterion and all criteria are stated only in the procurement documents
two.2.7) Duration of the contract, framework agreement or dynamic purchasing system
Duration in months
48
This contract is subject to renewal
No
two.2.10) Information about variants
Variants will be accepted: No
two.2.11) Information about options
Options: No
two.2) Description
two.2.1) Title
Primers and DNA Oligos
Lot No
3
two.2.2) Additional CPV code(s)
- 24000000 - Chemical products
two.2.3) Place of performance
NUTS codes
- UK - United Kingdom
two.2.4) Description of the procurement
CPI requires the synthesis of primers, DNA oligos, and gene synthesis services. CPI would require random primer sequences and the ability to buy custom synthesised primers for use in PCR/qPCR and would also require custom primer/ oligo synthesis, CPI will provide the sequence information for these primers to be synthesised. We would require primers to be produced at a selection of purities, such as HPLC and salt free. The supply of fluorescently labelled primer probes will also be required under this lot. For gene synthesis, CPI require a flexibility to synthesise a range of sequences varying in size (typically up to 4kb, with varying complexities) with use a variety of plasmid backbone options with a range of antibiotic resistance genes.
Due to the need for a quick turnaround on some of CPI's projects, it would be preferred for suppliers to be able to offer quick synthesis and next day delivery options. Web ordering would also be preferred to enable quick processing of our orders.
two.2.5) Award criteria
Price is not the only award criterion and all criteria are stated only in the procurement documents
two.2.7) Duration of the contract, framework agreement or dynamic purchasing system
Duration in months
48
This contract is subject to renewal
No
two.2.10) Information about variants
Variants will be accepted: No
two.2.11) Information about options
Options: No
two.2) Description
two.2.1) Title
Gel Consumables
Lot No
4
two.2.2) Additional CPV code(s)
- 24000000 - Chemical products
two.2.3) Place of performance
NUTS codes
- UK - United Kingdom
two.2.4) Description of the procurement
CPI would require consumables for the analysis of proteins and nucleic acids by gel electrophoresis. Consumables required include gel loading dyes; RNA, DNA and protein ladders and gel extraction kits. RNA and DNA ladders should span a range of sizes, up to 9kb. Concentrated gel running buffers such as 10XTAE, 10XTBE and MOPS is advantageous. The supply of other purification kits such as gel extraction kits and genomic DNA extraction kits are advantageous.
two.2.5) Award criteria
Price is not the only award criterion and all criteria are stated only in the procurement documents
two.2.7) Duration of the contract, framework agreement or dynamic purchasing system
Duration in months
48
This contract is subject to renewal
No
two.2.10) Information about variants
Variants will be accepted: No
two.2.11) Information about options
Options: No
two.2) Description
two.2.1) Title
Buffers
Lot No
5
two.2.2) Additional CPV code(s)
- 24000000 - Chemical products
two.2.3) Place of performance
NUTS codes
- UK - United Kingdom
two.2.4) Description of the procurement
Concentrated buffers and nuclease free water for use with their associated enzymes during reactions are required. Buffers may be used where specified by the manufacturer in applications which include restriction reactions and in vitro transcription reactions.
Buffers must be tested for exonuclease and endonuclease activity and a CoA must be available for each lot number. These buffers are likely to be used in both small scale and large-scale applications and so custom bulk volumes of buffers would be advantageous. GMP grade options are also advantageous.
two.2.5) Award criteria
Price is not the only award criterion and all criteria are stated only in the procurement documents
two.2.7) Duration of the contract, framework agreement or dynamic purchasing system
Duration in months
48
This contract is subject to renewal
No
two.2.10) Information about variants
Variants will be accepted: No
two.2.11) Information about options
Options: No
two.2) Description
two.2.1) Title
Competent Cells
Lot No
6
two.2.2) Additional CPV code(s)
- 24000000 - Chemical products
two.2.3) Place of performance
NUTS codes
- UK - United Kingdom
two.2.4) Description of the procurement
CPI would require competent cells to be supplied for use in cloning/sub-cloning, protein expression and gDNA/cDNA library production.
Competent cells should be in preparations which are free of animal products and should be shipped on dry ice
two.2.5) Award criteria
Price is not the only award criterion and all criteria are stated only in the procurement documents
two.2.7) Duration of the contract, framework agreement or dynamic purchasing system
Duration in months
48
This contract is subject to renewal
No
two.2.10) Information about variants
Variants will be accepted: No
two.2.11) Information about options
Options: No
two.2) Description
two.2.1) Title
RNA/DNA Synthesis and Purification Kits
Lot No
7
two.2.2) Additional CPV code(s)
- 24000000 - Chemical products
two.2.3) Place of performance
NUTS codes
- UK - United Kingdom
two.2.4) Description of the procurement
CPI require the supply of RNA and DNA purification kits. RNA/DNA purification kits can be either gravity flow, vacuum assisted or spin columns and should cover small scale through to large scale. Multiple types of PCR kits would be required for use in development activities at CPI also, such as RT-PCR and RT-qPCR kits.
two.2.5) Award criteria
Price is not the only award criterion and all criteria are stated only in the procurement documents
two.2.7) Duration of the contract, framework agreement or dynamic purchasing system
Duration in months
48
This contract is subject to renewal
No
two.2.10) Information about variants
Variants will be accepted: No
two.2.11) Information about options
Options: No
two.2) Description
two.2.1) Title
Media
Lot No
8
two.2.2) Additional CPV code(s)
- 24000000 - Chemical products
two.2.3) Place of performance
NUTS codes
- UK - United Kingdom
two.2.4) Description of the procurement
CPI require the supply of cell culture media to assist with the testing of therapeutic nucleic acids (DNA/RNA). Cell culture media and feeds are required, as either pre-made sterile solutions or as a powder.
two.2.5) Award criteria
Price is not the only award criterion and all criteria are stated only in the procurement documents
two.2.7) Duration of the contract, framework agreement or dynamic purchasing system
Duration in months
48
This contract is subject to renewal
No
two.2.10) Information about variants
Variants will be accepted: No
two.2.11) Information about options
Options: No
two.2) Description
two.2.1) Title
CleanCap
Lot No
9
two.2.2) Additional CPV code(s)
- 24000000 - Chemical products
two.2.3) Place of performance
NUTS codes
- UK - United Kingdom
two.2.4) Description of the procurement
CPI require supply of the RNA co-translational capping agent, cleancap. The supplier must be able to supply various types of therapeutically relevant cleancap analogues, such as AU and AG (in addition to the methylated form).
two.2.5) Award criteria
Price is not the only award criterion and all criteria are stated only in the procurement documents
two.2.7) Duration of the contract, framework agreement or dynamic purchasing system
Duration in months
48
This contract is subject to renewal
No
two.2.10) Information about variants
Variants will be accepted: No
two.2.11) Information about options
Options: No
two.2) Description
two.2.1) Title
Columns
Lot No
10
two.2.2) Additional CPV code(s)
- 24000000 - Chemical products
two.2.3) Place of performance
NUTS codes
- UK - United Kingdom
two.2.4) Description of the procurement
CPI require columns for use in packed column chromatography during the purification of in vitro transcribed mRNA. Where columns are not supplied pre-packed, suitable chromatography media should be supplied for manual column packing. Columns should be certified to sterile and free of ribonucleases. A CoA should be supplied for each lot. Columns may be used for small and large scale, preparative and analytical applications. As a result, the column length, diameter, media composition and mode of adsorption may vary significantly between purchases. Columns and media which comply with GMP specifications are preferred.
two.2.5) Award criteria
Price is not the only award criterion and all criteria are stated only in the procurement documents
two.2.7) Duration of the contract, framework agreement or dynamic purchasing system
Duration in months
48
This contract is subject to renewal
No
two.2.10) Information about variants
Variants will be accepted: No
two.2.11) Information about options
Options: No
two.2) Description
two.2.1) Title
AAV material
Lot No
11
two.2.2) Additional CPV code(s)
- 24000000 - Chemical products
two.2.3) Place of performance
NUTS codes
- UK - United Kingdom
two.2.4) Description of the procurement
CPI require AAV material as a control or standard for downstream and analytical assays such as ELISA and western blotting. This material would be used to check the validity of assays and act as a comparison to in-house generated samples. Further, the material would be used to develop and validate methods for different analyses prior to analysis of samples generated in-house. The material required would need to be of a high purity with the associated CoA for each item purchased.
two.2.5) Award criteria
Price is not the only award criterion and all criteria are stated only in the procurement documents
two.2.7) Duration of the contract, framework agreement or dynamic purchasing system
Duration in months
48
This contract is subject to renewal
No
two.2.10) Information about variants
Variants will be accepted: No
two.2.11) Information about options
Options: No
two.2) Description
two.2.1) Title
ELISA kits
Lot No
12
two.2.2) Additional CPV code(s)
- 24000000 - Chemical products
two.2.3) Place of performance
NUTS codes
- UK - United Kingdom
two.2.4) Description of the procurement
CPI require the supply of ELISA kits for the detection of proteins during the production of different therapeutics such host cell protein contaminants, recombinant therapeutic proteins and AAV particles. A range of kits are required that target and confirm the presence of specific protein targets in samples. For AAV analysis, different serotypes exist, and specific kits allow the distinction between these types and confirm the formation of AAV particles. ELISA kits are required to be specific to the intended target and include the CoA/quality control certificates.
two.2.5) Award criteria
Price is not the only award criterion and all criteria are stated only in the procurement documents
two.2.7) Duration of the contract, framework agreement or dynamic purchasing system
Duration in months
48
This contract is subject to renewal
No
two.2.10) Information about variants
Variants will be accepted: No
two.2.11) Information about options
Options: No
two.2) Description
two.2.1) Title
Reporter assay
Lot No
13
two.2.2) Additional CPV code(s)
- 24000000 - Chemical products
two.2.3) Place of performance
NUTS codes
- UK - United Kingdom
two.2.4) Description of the procurement
CPI require reporter assays as an efficient method to measure cell health during experiments. Assays allow of aspects such as product related toxicity and detect differences in cell growth. A range of kits are required that allow real-time measurements, compatibility with manual handling and/or automation. Reporter assays are required to provide high sensitivity, accurate, stable readouts and applicable across different cell types with the necessary CoA/quality control certificates.
two.2.5) Award criteria
Price is not the only award criterion and all criteria are stated only in the procurement documents
two.2.7) Duration of the contract, framework agreement or dynamic purchasing system
Duration in months
48
This contract is subject to renewal
No
two.2.10) Information about variants
Variants will be accepted: No
two.2.11) Information about options
Options: No
two.2) Description
two.2.1) Title
Transfection reagents
Lot No
14
two.2.2) Additional CPV code(s)
- 24000000 - Chemical products
two.2.3) Place of performance
NUTS codes
- UK - United Kingdom
two.2.4) Description of the procurement
CPI require the supply of transfection reagents to deliver nucleic acids in different formats (RNA/DNA) into cells for the testing or production of therapeutics. A wide range of reagents are required as the transfection reagent used can depend on the nucleic acid type, cell system and scale. Transfection reagents would be required in a sterile pre-made solution or as a powder for use at small and large-scale with the CoA/quality control certificates. GMP-grade material would also be advantageous.
two.2.5) Award criteria
Price is not the only award criterion and all criteria are stated only in the procurement documents
two.2.7) Duration of the contract, framework agreement or dynamic purchasing system
Duration in months
48
This contract is subject to renewal
No
two.2.10) Information about variants
Variants will be accepted: No
two.2.11) Information about options
Options: No
Section four. Procedure
four.1) Description
four.1.1) Type of procedure
Open procedure
four.1.8) Information about the Government Procurement Agreement (GPA)
The procurement is covered by the Government Procurement Agreement: Yes
four.2) Administrative information
four.2.1) Previous publication concerning this procedure
Notice number: 2021/S 211-557702
four.2.2) Time limit for receipt of tenders or requests to participate
Date
26 November 2021
Local time
12:00pm
four.2.4) Languages in which tenders or requests to participate may be submitted
English
four.2.7) Conditions for opening of tenders
Date
26 November 2021
Local time
1:00pm
Section six. Complementary information
six.1) Information about recurrence
This is a recurrent procurement: No
six.4) Procedures for review
six.4.1) Review body
CPI
Wilton
TS10 4RF
Country
United Kingdom