Section one: Contracting authority
one.1) Name and addresses
The NHS Commissioning Board (operating under the name of NHS England)
2nd Floor, Rutland House
Runcorn
WA7 2ES
Contact
Andrew Powell
Country
United Kingdom
NUTS code
UK - United Kingdom
Internet address(es)
Main address
Buyer's address
one.3) Communication
Additional information can be obtained from the above-mentioned address
Electronic communication requires the use of tools and devices that are not generally available. Unrestricted and full direct access to these tools and devices is possible, free of charge, at
one.4) Type of the contracting authority
Body governed by public law
one.5) Main activity
Health
Section two: Object
two.1) Scope of the procurement
two.1.1) Title
HGMD License Renewal
two.1.2) Main CPV code
- 85100000 - Health services
two.1.3) Type of contract
Services
two.1.4) Short description
The requirement is for a comprehensive and searchable manually curated literature-based database of germline human genomic variants and their relationship with human disease, with links to associated peer reviewed scientific literature references and variant classification. The successful provider will demonstrate class leading and significant experience in the area, peer reviewed publications illustrating utility in the diagnostic setting and that their database is up to date and covers the breadth of the peer-reviewed scientific literature.
two.1.5) Estimated total value
Value excluding VAT: £2,200,000
two.1.6) Information about lots
This contract is divided into lots: No
two.2) Description
two.2.2) Additional CPV code(s)
- 48218000 - License management software package
two.2.3) Place of performance
NUTS codes
- UK - United Kingdom
two.2.4) Description of the procurement
The requirement is for a comprehensive and searchable manually curated literature-based database of germline human genomic variants and their relationship with human disease, with links to associated peer reviewed scientific literature references and variant classification. The successful provider will demonstrate class leading and significant experience in the area, peer reviewed publications illustrating utility in the diagnostic setting and that their database is up to date and covers the breadth of the peer-reviewed scientific literature. The database must enable users to:1. Search extensively for rare and inherited disease associated variants;2. Search extensively for information relating to known variants associated with a particular disease;3. Search for gene and variant type, and specific variants, and link out to peer reviewed scientific literature;4. Have ease of accessibility and navigation of database pages;5. Download the database as a flat file with comprehensive variant annotation for integration into local bioinformatics pipelines that permits to link out to original scientific data sources.Pre-market EngagementNHS England & Improvement are currently undertaking an options appraisal and as part of this have issued a Notice to the market to gauge supplier interest and capability in relation to continuing the delivery of this service.Current thinking is that NHS England & Improvement will enter into a 36-month contract with an approximate total value of £2,200,000 exclusive of applicable VAT.Due to budget pressures expected to impact over the term, we expect for costs submitted to demonstrate a significant reduction upon the forecast, reflecting the stability offered by a three-year term.Please register your interest by 12pm 18/10/2021Interested suppliers should read the details in section VI.3 which specify further details about the requirement, how to register an interest in the possible procurement and the submission requirements for registering an interest.
two.2.14) Additional information
1. Suppliers are asked to describe, in detail, how their database meets EACH of the requirements numbered above. Each requirement is essential, and must be met in full. Suppliers may also choose to evidence how your database exceeds any, or all, of the requirements set out above.
two.3) Estimated date of publication of contract notice
30 December 2021
Section four. Procedure
four.1) Description
four.1.8) Information about the Government Procurement Agreement (GPA)
The procurement is covered by the Government Procurement Agreement: No
Section six. Complementary information
six.3) Additional information
Interested suppliers should register on the NHS England & Improvement e-procurement system here: https://health-family.force.com/login• Once logged in click 'Find Opportunities' and search for ‘HGMD License Renewal’• Click 'Register Interest' • Once you have registered your interest you will be able to view the Requirements and submit a response to the question within the portal (see Annex A for details).• Any messages about the opportunity should be sent via the e-procurement system. You can do this by going to the home page and:o Click on 'My proposals & Quotes' o Click the relevant Project Title o Click 'Messages' & 'New Message' The deadline for submitting Expressions of Interest is 12pm on 18/10/2021Submission Requirements on the Portal:Once registered via the e-Portal Atamis you will be able to submit responses to the following question to demonstrate your experience and capability to deliver the programme. QUESTION: Suppliers are asked to describe, in detail, how their database meets EACH of the requirements numbered below. Each requirement is essential and must be met in full. Suppliers may also choose to evidence how your database exceeds any, or all, of the requirements set out above.Requirements:- The database must enable users to:1. Search extensively for rare and inherited disease associated variants;2. Search extensively for information relating to known variants associated with a particular disease;3. Search for gene and variant type, and specific variants, and link out to peer reviewed scientific literature;4. Have ease of accessibility and navigation of database pages;5. Download the database as a flat file with comprehensive variant annotation for integration into local bioinformatics pipelines that permits to link out to original scientific data sources.