Section one: Contracting authority/entity
one.1) Name and addresses
Cardiff University
Procurement Services, McKenzie House, 30-36 Newport Road
Cardiff
CF24 0DE
Telephone
+44 2920879648
Country
United Kingdom
NUTS code
UKL - Wales
Internet address(es)
Main address
http://www.cardiff.ac.uk/business/why-work-with-us/for-suppliers
Buyer's address
https://www.sell2wales.gov.wales/search/Search_AuthProfile.aspx?ID=AA0258
one.4) Type of the contracting authority
Body governed by public law
one.5) Main activity
Education
Section two: Object
two.1) Scope of the procurement
two.1.1) Title
GeoMx Digital Spatial Profiler and nCounter
Reference number
CU.732.TH
two.1.2) Main CPV code
- 38432000 - Analysis apparatus
two.1.3) Type of contract
Supplies
two.1.4) Short description
NanoString GeoMX and nCounter instruments
two.1.6) Information about lots
This contract is divided into lots: No
two.1.7) Total value of the procurement (excluding VAT)
Value excluding VAT: £300,000
two.2) Description
two.2.2) Additional CPV code(s)
- 38432000 - Analysis apparatus
two.2.3) Place of performance
NUTS codes
- UKL22 - Cardiff and Vale of Glamorgan
two.2.4) Description of the procurement
The GeoMx DSP is a novel digital technology (proprietary
to NanoString) that is based on multiplexed measurement
of protein and nucleic acids and offers unparalleled levels of
precision coupled with the ability to quantify up to 96 proteins
and over 1000 RNA targets on a formalin-fixed, paraffinembedded
(FFPE) tissue section on a microscope slide.
two.2.11) Information about options
Options: No
two.2.13) Information about European Union Funds
The procurement is related to a project and/or programme financed by European Union funds: No
Section four. Procedure
four.1) Description
four.1.1) Type of procedure
Award of a contract without prior publication of a call for competition in the cases listed below
- The procurement falls outside the scope of application of the regulations
Explanation:
The GeoMx Digital Spatial Profiler (DSP)
is only available from NanoString
Technologies, Inc.
The GeoMx DSP is a novel digital technology (proprietary
to NanoString) that is based on multiplexed measurement
of protein and nucleic acids and offers unparalleled levels of
precision coupled with the ability to quantify up to 96 proteins
and over 1000 RNA targets on a formalin-fixed, paraffinembedded
(FFPE) tissue section on a microscope slide.
In contrast to the sequential analysis of multi-target
immunohistochemistry (IHC) slides, the GeoMx DSP samples
all protein or RNA analytes on a single slide. This not only
shortens experiments and simplifies data analysis, but also
provides a higher multiplexing capacity (96 targets) all with
spatial context from Formalin-Fixed, Paraffin-Embedded
(FFPE) tissue sections.
Based on NanoString’s proprietary digital barcoding
technology, the GeoMx DSP platform measures local protein
levels, and can be combined with RNA expression, within
heterogeneous tissue samples. Combining both multiplexed
nucleic acid and protein on the same platform gives
researchers the ability to spatially resolve RNA when suitable
antibodies do not exist. The GeoMx DSP assay is performed on
the GeoMx DSP platform which includes imaging and fluidic
components to capture spatial context, and current nCounter®
or next-generation sequencing (NGS) instruments provide the
quantification.
Protein detection is enabled via primary antibodies which
are covalently attached via a UV photocleavable linker to
DNA indexing oligos. Following antigen retrieval, FFPE tissue
samples are stained with a multiplexed cocktail of labeled
antibodies, and DNA oligos are subsequently released by
UV light exposure across regions of interest. The liberated
DNA oligos are then hybridized to optical barcodes for
quantitation on an nCounter or NGS instrument. This
technique enables quantitative, multiplexed protein detection
up to 5.5 logs of dynamic range.
Key Features and Benefits of DSP technology
- Multiplex many analytes on one tissue section in
a single pass
- Quantitation based on linear single-molecule
counting: up to 5.5 logs
- Single-cell limit of detection
- Non-destructive: sample completely intact after assay
- Single antigen retrieval without effects from
order-of-addition
four.1.8) Information about the Government Procurement Agreement (GPA)
The procurement is covered by the Government Procurement Agreement: Yes
Section five. Award of contract/concession
Contract No
CU.732.TH
A contract/lot is awarded: Yes
five.2) Award of contract/concession
five.2.1) Date of conclusion of the contract
15 September 2021
five.2.2) Information about tenders
The contract has been awarded to a group of economic operators: No
five.2.3) Name and address of the contractor/concessionaire
NanoString Technologies
St. Marys Court, The Broadway
Amersham
HP70UT
Telephone
+44 7468604366
Country
United Kingdom
NUTS code
- UK - United Kingdom
The contractor/concessionaire is an SME
Yes
five.2.4) Information on value of contract/lot/concession (excluding VAT)
Total value of the contract/lot/concession: £300,000
Section six. Complementary information
six.3) Additional information
(WA Ref:114050)
six.4) Procedures for review
six.4.1) Review body
High Court
Royal Courts of Justice, The Strand
London
WC2A 2LL
Telephone
+44 2079477501
Country
United Kingdom