Section one: Contracting authority
one.1) Name and addresses
UNIVERSITY OF MANCHESTER
John Owens Building, Oxford Road
MANCHESTER
M13 9PL
Contact
Paul Carter
paul.carter-2@manchester.ac.uk
Country
United Kingdom
Region code
UKD33 - Manchester
UK Register of Learning Providers (UKPRN number)
10007798
Internet address(es)
Main address
http://www.procurement.manchester.ac.uk/
one.3) Communication
The procurement documents are available for unrestricted and full direct access, free of charge, at
https://in-tendhost.co.uk/manchesteruniversity/aspx/Tenders/Current
Additional information can be obtained from the above-mentioned address
Tenders or requests to participate must be submitted electronically via
https://in-tendhost.co.uk/manchesteruniversity/aspx/Tenders/Current
one.4) Type of the contracting authority
Body governed by public law
one.5) Main activity
Education
Section two: Object
two.1) Scope of the procurement
two.1.1) Title
Integrated bioreactor platform for rapid scale-up and translation
Reference number
2023-2033-BRS-JW-PC
two.1.2) Main CPV code
- 42993000 - Chemical industry machinery
two.1.3) Type of contract
Supplies
two.1.4) Short description
This tender is being run on behalf of Dr James Winterburn, Reader in Chemical Engineering. Dr Winterburn led a successful BBSRC ALERT21 equipment bid "Integrated bioreactor platform for rapid scale-up and translation", which will provide significant bioreactor capacity for microbial fermentation process development, scale up and translation for a range of bio-based chemicals. The exploitation of bio-based production routes requires a thorough understanding of production strain performance and an ability to rapidly and effectively scale processes from millilitres to tens of litres. The bioreactor platform is intended to provide understanding of how process conditions at different volumes and variability across process parameters (e.g., mixing speeds, dissolved O2, pH), affect host cell performance. The integrated bioreactor platform will bridge across three scales, outlined below, and allow for rapid process development and ultimately support research translation.
Small-scale: Parallel bioreactor system (500 mL, 6 vessels) for rapid parallel process development, strain testing and parameter optimization for microbial fermentations in batch, fed-batch and continuous cultivation, with off gas analysis capability
Mid-scale (3L bioreactor system, four vessels): For initial scale up and process development work (e.g., confirmation of feeding profiles, metabolic profiling) and preliminary process analysis (including; yield, productivity, final titre) with off gas analysis capability. Also serves as the seed train for inoculum preparation for scale up to 40L.
Large-scale feasibility (40L SIP bioreactor): To enable in-house demonstration of process technical feasibility, production of sufficient quantities of material for application testing and benchmarking and provision of data for robust techno-economic analysis which can be used as the basis for commercialisation, also with off gas analysis capability.
two.1.6) Information about lots
This contract is divided into lots: No
two.2) Description
two.2.2) Additional CPV code(s)
- 38000000 - Laboratory, optical and precision equipments (excl. glasses)
two.2.3) Place of performance
NUTS codes
- UKD3 - Greater Manchester
Main site or place of performance
The University of Manchester
two.2.4) Description of the procurement
This tender is being run on behalf of Dr James Winterburn, Reader in Chemical Engineering. Dr Winterburn led a successful BBSRC ALERT21 equipment bid "Integrated bioreactor platform for rapid scale-up and translation", which will provide significant bioreactor capacity for microbial fermentation process development, scale up and translation for a range of bio-based chemicals. The exploitation of bio-based production routes requires a thorough understanding of production strain performance and an ability to rapidly and effectively scale processes from millilitres to tens of litres. The bioreactor platform is intended to provide understanding of how process conditions at different volumes and variability across process parameters (e.g., mixing speeds, dissolved O2, pH), affect host cell performance. The integrated bioreactor platform will bridge across three scales, outlined below, and allow for rapid process development and ultimately support research translation.
Small-scale: Parallel bioreactor system (500 mL, 6 vessels) for rapid parallel process development, strain testing and parameter optimization for microbial fermentations in batch, fed-batch and continuous cultivation, with off gas analysis capability
Mid-scale (3L bioreactor system, four vessels): For initial scale up and process development work (e.g., confirmation of feeding profiles, metabolic profiling) and preliminary process analysis (including; yield, productivity, final titre) with off gas analysis capability. Also serves as the seed train for inoculum preparation for scale up to 40L.
Large-scale feasibility (40L SIP bioreactor): To enable in-house demonstration of process technical feasibility, production of sufficient quantities of material for application testing and benchmarking and provision of data for robust techno-economic analysis which can be used as the basis for commercialisation, also with off gas analysis capability.
two.2.5) Award criteria
Price is not the only award criterion and all criteria are stated only in the procurement documents
two.2.7) Duration of the contract, framework agreement or dynamic purchasing system
Start date
8 June 2023
End date
14 February 2024
This contract is subject to renewal
No
two.2.10) Information about variants
Variants will be accepted: No
two.2.11) Information about options
Options: No
Section four. Procedure
four.1) Description
four.1.1) Type of procedure
Open procedure
four.1.8) Information about the Government Procurement Agreement (GPA)
The procurement is covered by the Government Procurement Agreement: Yes
four.2) Administrative information
four.2.2) Time limit for receipt of tenders or requests to participate
Date
25 May 2023
Local time
12:00pm
four.2.4) Languages in which tenders or requests to participate may be submitted
English
four.2.6) Minimum time frame during which the tenderer must maintain the tender
Duration in months: 3 (from the date stated for receipt of tender)
four.2.7) Conditions for opening of tenders
Date
25 May 2023
Local time
12:05pm
Place
The University of Manchester
Information about authorised persons and opening procedure
The University of Manchester staff only
Section six. Complementary information
six.1) Information about recurrence
This is a recurrent procurement: No
six.2) Information about electronic workflows
Electronic ordering will be used
Electronic invoicing will be accepted
Electronic payment will be used
six.4) Procedures for review
six.4.1) Review body
The University of Manchester
Manchester
Country
United Kingdom