Section one: Contracting authority/entity
one.1) Name and addresses
Scottish National Blood Transfusion Service
The Jack Copland Centre, 52 Research Avenue, Heriot-Watt Research Park
Edinburgh
EH14 4BE
Contact
Ramsay Walls
Telephone
+44 1313145603
Country
United Kingdom
NUTS code
UKM - SCOTLAND
Internet address(es)
Main address
Buyer's address
https://www.publiccontractsscotland.gov.uk/search/Search_AuthProfile.aspx?ID=AA12722
one.4) Type of the contracting authority
Body governed by public law
one.5) Main activity
Health
Section two: Object
two.1) Scope of the procurement
two.1.1) Title
Purchase of High Content Screening System
two.1.2) Main CPV code
- 38518100 - Wide field microscopes
two.1.3) Type of contract
Supplies
two.1.4) Short description
Delivery of an Operetta CLS high-content screening system
two.1.6) Information about lots
This contract is divided into lots: No
two.1.7) Total value of the procurement (excluding VAT)
Lowest offer: £200,000 / Highest offer: £300,000 taken into consideration
two.2) Description
two.2.3) Place of performance
NUTS codes
- UKM75 - Edinburgh, City of
two.2.4) Description of the procurement
Supply, installation and training of High Content Screening System Operetta CLS equipment for the detailed analysis of a variety of cell types (including rare cells such as stem cells and antigen-specific T cells) and for more specialist applications including: imaging of primary cells, live cells and cells cultured in 3D systems, tumorigenesis analysis including colony detection, phagocytosis assays, size and shape analysis, quantification of cells/colonies and fluorescence; by TCAT (Tissues, Cells and Advanced Therapeutics), Scottish National Blood Transfusion Service (SNBTS).
The following specific aspects of operetta CLS are strictly necessary for our research and are not provided by any other provider:
— With 8 high-performance LEDs, the Operetta CLS offers an unsurpassed variety of excitation wavelengths for the entire range between ultraviolet and near-infrared. This flexibility is of immense importance for QC development of a wide variety of assays
— The Operetta CLS has a user-accessible 8-position emission filter wheel, which can be equipped with barcode filters for error-free operation, and for optimal coincidence between excitation and emission source.
.— The Operetta CLS can be equipped with 3 automated water immersion lenses with high numerical aperture of various magnifications (20x, 40x, 63x). This shortens the measurement time and improves the resolution in the z-direction; overall, this increases throughput in the analysis of three-dimensional structures. This is necessary for the exact analysis of the many different samples that are measured in our central department (tissue sections, tumor organoids, cell culture experiments, etc.). This technology is patented: EP1386189 B1, US7304793 B2 and EP1646902 B1, US7961384 B2.
— The system automatically corrects displacements resulting from the 5x to the 40x or 63x lens by means of a fluorescent reference sample (QuasiperiodicGrid) firmly installed in the table. This ensures that the desired cells, cell complexes, or cell structures can be found again and again at the
right level. Perkin Elmer also has a patent (US9582864). The ability to pre-scan and return to the same spot reduces the amount of time that cells are expose3d to incident illumination and therefore limits damage to the cells, this allows repeat analysis and temporal tracking.
— That the equipment software offers advanced morphological characteristics that allow the quantification of various aspects of the shape and structure of objects, for example: elongation, symmetry, smoothness of the edge and spatial distribution of the intensity of the texture characteristics,
— The system offers a method for machine learning (PhenoLOGIC) during analysis. This allows the software to identify different cell populations or regions and then automatically set the best parameters for optimal image segmentation and cell classification (patents to PhenoLOGIC:WO2013038224).
two.2.11) Information about options
Options: Yes
Description of options
On-going annual maintenance will also be required.
two.2.13) Information about European Union Funds
The procurement is related to a project and/or programme financed by European Union funds: No
Section four. Procedure
four.1) Description
four.1.1) Type of procedure
Negotiated without a prior call for competition
- The works, supplies or services can be provided only by a particular economic operator for the following reason:
- absence of competition for technical reasons
Explanation:
The following specific and unique selling points of operetta CLS are strictly necessary for our research and are not provided by any other provider:
— With 8 high-performance LEDs, the Operetta CLS offers an unsurpassed variety of excitation wavelengths for the entire range between ultraviolet and near-infrared. This flexibility is of immense importance for QC development of a wide variety of assays
— The Operetta CLS has a user-accessible 8-position emission filter wheel, which can be equipped with barcode filters for error-free operation, and for optimal coincidence between excitation and emission source.
.— The Operetta CLS can be equipped with 3 automated water immersion lenses with high numerical aperture of various magnifications (20x, 40x, 63x). This shortens the measurement time and improves the resolution in the z-direction; overall, this increases throughput in the analysis of three-dimensional structures. This is necessary for the exact analysis of the many different samples that are measured in our central department (tissue sections, tumor organoids, cell culture experiments, etc.). This technology is patented: EP1386189 B1, US7304793 B2 and EP1646902 B1, US7961384 B2.
— The system automatically corrects displacements resulting from the 5x to the 40x or 63x lens by means of a fluorescent reference sample (QuasiperiodicGrid) firmly installed in the table. This ensures that the desired cells, cell complexes, or cell structures can be found again and again at the
right level. Perkin Elmer also has a patent (US9582864). The ability to pre-scan and return to the same spot reduces the amount of time that cells are expose3d to incident illumination and therefore limits damage to the cells, this allows repeat analysis and temporal tracking.
— That the equipment software offers advanced morphological characteristics that allow the quantification of various aspects of the shape and structure of objects, for example: elongation, symmetry, smoothness of the edge and spatial distribution of the intensity of the texture characteristics,
— The system offers a method for machine learning (PhenoLOGIC) during analysis. This allows the software to identify different cell populations or regions and then automatically set the best parameters for optimal image segmentation and cell classification (patents to PhenoLOGIC:WO2013038224).
four.1.8) Information about the Government Procurement Agreement (GPA)
The procurement is covered by the Government Procurement Agreement: Yes
Section five. Award of contract/concession
A contract/lot is awarded: Yes
five.2) Award of contract/concession
five.2.1) Date of conclusion of the contract
22 January 2021
five.2.2) Information about tenders
The contract has been awarded to a group of economic operators: No
five.2.3) Name and address of the contractor/concessionaire
Perkin Elmer
Chalfont Road, Seer Green
Beaconsfield
HP9 2FX
Telephone
+44 800896046
Fax
+44 800891714
Country
United Kingdom
NUTS code
- UK - UNITED KINGDOM
The contractor/concessionaire is an SME
No
five.2.4) Information on value of contract/lot/concession (excluding VAT)
Lowest offer: £200,000 / Highest offer: £300,000 taken into consideration
Section six. Complementary information
six.3) Additional information
NOTE: To register your interest in this notice and obtain any additional information please visit the Public Contracts Scotland Web Site at https://www.publiccontractsscotland.gov.uk/Search/Search_Switch.aspx?ID=641947.
(SC Ref:641947)
six.4) Procedures for review
six.4.1) Review body
Edinburgh Sheriff Court
Sheriff Court House
Edinburgh
EH1 1LB
Country
United Kingdom