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must:\n• Be capable of multiplate/vessel imaging, up to a capacity of 6 plates/vessels and\nincluding capacity to image 6 384 well plates, to meet the volume of analysis that the\ncentre is undertaking and support high throughput drug screening projects.\n• Enable high resolution fluorescence and bright field images to be captured and recorded\nin real time over hours, days, or weeks. \n• Offer flexibility to enable users to observe and quantify complex biological changes over\ntime in cells and 3d structures such as spheroids and organoid models.\n• Include a fully integrated image acquisition system to capture real-time insight into\nmorphological and phenotypic changes and allow multiple users the opportunity to\nperform complex cellular assays.\n• Offer versatile assay configurations, supporting various experimental formats such as 2d\ncell systems and 3d spheroid, and organoid models.\nThe procurement of this live cell imaging system directly supports FMI’s broader goals of:\n• Accelerating drug discovery through rapid identification and characterisation of\ntherapeutic candidates\n• Providing screening capabilities in high-throughput format\n• Facilitating translational research by bridging fundamental cellular studies with\ntherapeutic applications.\nThe procurement of a live cell imaging system will provide direct benefit to research\nscientists within FMI, and wider stakeholders such as partner organisations and the wider\nacademic community in Queens University Belfast (QUB) by:\n• Significantly enhance its cellular screening capabilities.\n• Enhancing live cell imaging capabilities and data acquisition throughput in optimised\ncellular conditions.\n• Reducing time in setting up multiple vessels for multiple time point experiments.\n• Reducing plasticware consumables and expensive reagents currently used in setting up\nmultiple time point experiments. \nIf funding becomes available to address future expansion needs the University reserves\nthe right to 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